Ferrous Sulfide/Aqueous Ammonia: Simple, Efficient, and Chemoselective Reagent for the Conversion of Aromatic Azide to Amine

Abstract

A practical, environmentally benign, rapid, and efficient method for the reduction of aromatic azide to amine is described using FeS/aqueous ammonia in the presence of other reducible functionalities. Application of a novel reducing reagent results in aromatic amines with excellent yield and high chemoselectivity, without need of any purification techniques.

Keywords:

• azides
• chemoselectivity
• FeS/Aq · NH₃
• reduction

Acknowledgments

Amol V. Gadakh gratefully thanks C. S. N. Murthy, CEO, M/s. Aurigene Discovery Technologies Limited, Bangalore, India, for his constant motivation and support.