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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 2
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Original Articles

One‐Pot Synthesis of 4,6‐Diaryl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitriles via Three‐Component Cyclocondensation under Solvent‐Free Conditions

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Pages 217-224 | Received 30 Dec 2006, Published online: 18 Jan 2008
 

Abstract

An efficient and facile synthesis of 4,6‐diaryl‐2‐oxo‐1,2‐dihydropyridine‐3‐carbonitriles via three‐component cyclocondensation from aromatic aldehydes, aromatic ketones, and 2‐cyanoacetamide under solvent‐free conditions is described. The mild reaction conditions, simple protocol, and clean reaction make this protocol practical and economically attractive.

Acknowledgment

We thank the National Natural Science Foundation of China (No. 20372057) and Natural Science Foundation (No. 06XLA09) of Xuzhou Normal University for financial support.

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