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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 2
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Original Articles

Efficient Synthesis of 1‐Aryl‐1H‐indazole Derivatives via Copper(I)‐Catalyzed Intramolecular Amination Reaction

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Pages 249-254 | Received 05 May 2007, Published online: 18 Jan 2008
 

Abstract

A copper(I)‐catalyzed intramolecular amination reaction using CuI, KOH, and 1,4‐dioxane at 105°C for the preparation of 1‐aryl‐1H‐indazole derivatives was described. The method was applied to a wide scope of substrates and afforded indazole products in high yields.

Acknowledgment

This work was partially supported by the National Natural Science Foundation of China (Grants 20472062 and 20672079) and the Natural Science Foundation of Jiangsu Province (No. BK2006048).

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