Synthesis and Characterization of Tetraazaparacyclophane Disulfone

Abstract

1,6,20,25‐Tetraaza[6.1.6.1]paracyclophane‐13,32‐disulfone D was synthesized under a very dilute condition by the cyclization between tetramethylene dibromide and N,N′‐di‐p‐tosylaminodiphenylsulfone B, which was prepared using N,N′‐diaminodiphenyl sulfone and p‐toluenesulfonyl as raw materials. 1,6,20,25‐Tetra‐sulfoferrocene‐1,6,20,25‐tetraaza[6.1.6.1]paracyclophane‐13,32‐disulfone E was prepared by modifying D with the bioactive unit ferrocene. The structures were confirmed by IR, ¹H NMR, and elemental analysis.

Keywords:

• diphenylsulfone
• ferrocene
• tetraazaparacyclophane
• very dilute condition

Acknowledgments

The authors thank the Chinese National Natural Science Foundation (No. 20572085) and Shannxi Science Foundation (No. 2005B20) for financial support.