Ring‐Opening Reaction of 2‐Amino‐4,5‐dihydro‐3‐furancarbonitriles with Carboxylic Acids under Solvent‐Free Conditions

Abstract

The novel preparation of 2‐cyanobutanamide derivatives starting from 2‐amino‐4,5‐dihydro‐3‐furancarbonitriles is described. Thermal treatment of 4,5‐dihydro‐2‐(4‐morpholinyl, 1‐piperidinyl, and 1‐pyrrolidinyl)‐3‐furancarbonitriles with various carboxylic acids in the absence of solvent caused a ring‐opening reaction to give the corresponding 2‐cyanobutanamide derivatives.

Keywords:

• 2,3‐dihydrofurans
• carboxylic acids
• ringopening