Microwave‐Assisted Dehalogenation of α‐Haloketones by Zinc and Ammonium Chloride in Alcohol

Jian Li State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

Deju Ye State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

Hong Liu State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaCorrespondence[email protected]

Xiaoming Luo State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

Hualiang Jiang State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; School of Pharmacy, East China University of Science and Technology, Shanghai, China

Abstract

The treatment of α‐haloketones with 1.5 equiv. of Zn and 1 equiv. of NH₄Cl in ethanol for 0.5 min gave the corresponding ketones with excellent yields under microwave irradiation. Vic‐dibromides and 2,2‐dibromoacetophenone can be efficiently debrominated to alkenes and acetophenones, respectively.

Keywords:

Acknowledgments

We gratefully acknowledge financial support from the State Key Program of Basic Research of China (Grant 2002CB512802, 2005BA711A01), the National Natural Science Foundation of China (Grants 30672539, 20572117, and 20472094), and the 863 Hi‐Tech Program (Grants 2006AA020402, 2006AA020602, and 2006AA020402).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Microwave‐Assisted Dehalogenation of α‐Haloketones by Zinc and Ammonium Chloride in Alcohol

Information for

Open access

Opportunities

Help and information

Microwave‐Assisted Dehalogenation of α‐Haloketones by Zinc and Ammonium Chloride in Alcohol

Abstract

Acknowledgments

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature