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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 4
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Original Articles

Synthesis and Characterization of Potential Impurities of the Antimigraine Drug, Rizatriptan Benzoate

, , , , &
Pages 603-612 | Received 22 Aug 2007, Published online: 27 Feb 2008
 

Abstract

Rizatriptan benzoate is a recently developed antimigraine drug used for the treatment of migraines and severe headaches. In the synthesis of rizatriptan benzoate in bulk,various impurities are formed. The present work details the development of a simple and novel process for the preparation of hydrazone impurity (6), rizatriptan N‐oxide (7), rizatriptan dimer (9), desmethyl rizatriptan (13), 5‐(1H‐1,2,4‐triazol‐1‐yl‐methyl)‐1H‐indole‐3‐ethanamine hydrochloride (14), N‐methyl rizatriptan oxalate (15), and impurities.

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Erratum

Acknowledgments

The authors thank the management of Dr. Reddy's Laboratories Ltd. for supporting this work.

Notes

DRL Communication No ‐IPDO‐IPM00063

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