Abstract
Rizatriptan benzoate is a recently developed antimigraine drug used for the treatment of migraines and severe headaches. In the synthesis of rizatriptan benzoate in bulk,various impurities are formed. The present work details the development of a simple and novel process for the preparation of hydrazone impurity (6), rizatriptan N‐oxide (7), rizatriptan dimer (9), desmethyl rizatriptan (13), 5‐(1H‐1,2,4‐triazol‐1‐yl‐methyl)‐1H‐indole‐3‐ethanamine hydrochloride (14), N‐methyl rizatriptan oxalate (15), and impurities.
Acknowledgments
The authors thank the management of Dr. Reddy's Laboratories Ltd. for supporting this work.
Notes
DRL Communication No ‐IPDO‐IPM00063