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Abstract
Graphical Abstract Section
Graphical Abstracts
Synth. Commun. 2008, 38, 482
PREPARATION OF 5‐ARYL‐3‐OXO‐δ‐LACTONES BY THE POTASSIUM CARBONATE–PROMOTED CONDENSATION OF AROMATIC ALDEHYDES AND ETHYL ACETOACETATE IN ETHANOL
Brad Andersh, Jessica Gereg, Mical Amanuel, and Carl Stanley
Department of Chemistry and Biochemistry, Bradley University, Peoria, Illinois, USA
Abstract
Synth. Commun. 2008, 38, 489
ALUMINOSILICATE CATALYSIS OF CHALCONE DIELS–ALDER REACTIONS
Jennifer L. Corbett and Rex T. Weavers
Department of Chemistry, University of Otago, Dunedin, New Zealand
Use of a nanoporous aluminosilicate catalyst enables facile preparation of new Diels–Alder adducts of chalcones with isoprene or myrcene.
Abstract
Synth. Commun. 2008, 38, 499
SYNTHESIS OF HYDROXYALKYL‐SUBSTITUTED, PUSH–PULL CHROMOPHORES BASED ON DIPHENYLACETYLENES AND 1,4‐BIS(PHENYLETHYNYL)BENZENES
Tara A. Cross and Matthew C. Davis
Chemistry and Materials Division, Michelson Laboratory, Naval Air Warfare Center, China Lake, California, USA
Abstract
Synth. Commun. 2008, 38, 517
CONVENIENT PREPARATION OF OPTICALLY PURE 3‐ARYLOXY‐PYRROLIDINES
Christophe Bénard,1 Rahim Mohammad,1 Neerja Saraswat,1 Rudong Shan,1 Samarendra N. Maiti,1 Peter G. M. Wuts,2 Michael Stier,2 Teresa Lints,2 James Bradow,2 and Jacob B. Schwarz2
1Naeja Pharmaceutical Research and Development, Edmonton, Alberta, Canada
2Pfizer Global Research and Development, Groton, Connecticut, USA
The pyrroline by‐product of elimination was easily removed through aqueous partitioning and/or concentration, furnishing chiral pyrrolidines in high chemical purity.
Abstract
Synth. Commun. 2008, 38, 525
EFFICIENT METHOD FOR THE SYNTHESIS OF TECTORIGENIN
Zhu‐Ping Xiao1,2, Huan‐Qiu Li1, Jia‐Yu Xue1, Lei Shi1, and Hai‐Liang Zhu1
1Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
2Department of Chemistry, Shangrao Normal College, Shangrao, China
Abstract
Synth. Commun. 2008, 38, 530
SYNTHESIS AND CHARACTERIZATION OF TETRAAZAPARACYCLOPHANE DISULFONE
Y.-T. Yang, B.-Q. Yang, M. Li, W. Ning, and Z.-H. Lu
Shannxi Key Laboratory of Physical Inorganic Chemistry, Department of Chemistry, Northwest University, Xi'an, Shannxi, China
1,6,20,25‐Tetraaza[6.1.6.1]paracyclophane‐13,32‐disulfone D was synthesized under a high dilute condition by the cyclization between tetramethylene dibromide and N,N′‐di‐p‐tosylaminodiphenylsulfone B, which was prepared using N,N′‐diaminodiphenyl sulfone and p‐toluenesulfonyl as raw materials. 1,6,20,25‐tetra‐sulfoferrocene‐1,6,20,25‐tetraaza[6.1.6.1]paracyclophane‐13,32‐disulfone E was prepared by modifying D with bioactive unit ferrocene. The structures were confirmed by IR, 1H NMR, and elemental analysis.
Abstract
Synth. Commun. 2008, 38, 537
NITRATION OF SIMPLE AROMATICS WITH NO2 UNDER AIR ATMOSPHERE IN THE PRESENCE OF NOVEL BRØNSTED ACIDIC IONIC LIQUIDS
Xiufang Qi, Guangbin Cheng, Chunxu Lu, and Desheng Qian
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, China
Abstract
Synth. Commun. 2008, 38, 546
MANNICH‐TYPE REACTION CATALYZED BY SILICA‐SUPPORTED FLUOROBORIC ACID UNDER SOLVENT‐FREE CONDITIONS
WeiYi Chen,1 XinSheng Li,2 and Jun Lu1
1College of Chemistry and Chemical Engineering of Suzhou University, Suzhou, China
2Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua, China
Three‐component Mannich‐type reaction of aldehydes, aromatic amines, and silyl enolate proceeded smoothly to afford β‐amino carbonyl compounds with good yields in the presence of a catalytic amount of HBF4‐SiO2.
Abstract
Synth. Commun. 2008, 38, 553
FIRST CATENANE CONTAINING PHOSPHINO GROUPS: A STEP TOWARD A CATENANE LIGAND
Manabu Yamazaki, Toshiki Hagiwara, Masahiro Sekiguchi, Takashi Sawaguchi, and Shoichiro Yano
Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Chiyoda-ku, Tokyo, Japan
Abstract
Synth. Commun. 2008, 38, 559
RING‐OPENING REACTION OF 2‐AMINO‐4,5‐DIHYDRO‐3‐FURANCARBONITRILES WITH CARBOXYLIC ACIDS UNDER SOLVENT‐FREE CONDITIONS
Hiroshi Maruoka, Fumi Okabe, and Kenji Yamagata,
Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
Abstract
Synth. Commun. 2008, 38, 567
MICROWAVE‐ASSISTED DEHALOGENATION OF α‐HALOKETONES BY ZINC AND AMMONIUM CHLORIDE IN ALCOHOL
Jian Li,1 Deju Ye,1 Hong Liu,1 Xiaomin Luo,1 and Hualiang Jiang1,2
1Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
2School of Pharmacy, East China University of Science and Technology, Shanghai, China
The treatment of α‐haloketones with 1.5 equiv. of Zn and 1 equiv. of NH4Cl in ethanol for 0.5 min gave the corresponding ketones with excellent yields under microwave irradiation. Vic‐dibromides and 2,2‐dibromoacetophenone can be efficiently debrominated to alkenes and acetophenones respectively.
Abstract
Synth. Commun. 2008, 38, 576
IMPROVED SYNTHETIC APPROACH TO TENATOPRAZOLE
Liyan Dai, Dongbo Fan, Xiaozhong Wang, and Yingqi Chen
Institute of Pharmaceutical Engineering, College of Materials Science and Chemical Engineering, Zhejiang University, Hangzhou, Zhejiang, China
An improved synthetic approach to Tenatoprazole is described.
Abstract
Synth. Commun. 2008, 38, 583
NOVEL METHOD FOR SOLUBLE‐POLYMER‐SUPPORTED SYNTHESIS OF 3,4,5‐TRISUBSTITUTED ISOXAZOLES
Yongjia Shang, Lianbing Ren, and Jianwei Wu
College of Chemistry and Materials Science, Anhui Key Laboratory of Functional Molecular Solids, Anhui Normal University, Wuhu, China
A practical and efficient liquid‐phase synthesis of isoxazoles using poly(ethylene glycol) as supported was described. Soluble‐polymer‐supported nitrile oxide generated in situ reacts with chalcones to afford isoxazolines, which were cleaved by sodium methoxide to generate isoxazoles instead of isoxazolines.
Abstract
Synth. Commun. 2008, 38, 595
(NH4)3PW12O40 AS AN EFFICIENT AND REUSABLE CATALYST FOR THE SYNTHESIS AND DEPROTECTION OF 1,1‐DIACETATES
Jitendra R. Satam and Radha V. Jayaram
Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga Mumbai, India
Abstract
Synth. Commun. 2008, 38, 603
SYNTHESIS AND CHARACTERIZATION OF POTENTIAL IMPURITIES
P. Seetharama Sarma,1 C. Nageswar Rao,1 M. V. Surayanarayana,2 Padi Pratap Reddy,1 M. Khalilluah,2 and Cherukupally Praveen1
1Research and Development Centre, Integrated Product Development Organization‐Active Pharmaceutical Ingredients, Dr. Reddy's Laboratories Ltd., Bachupally, Hyderabad 506 055, Andhra Pradesh, India
2Department of Chemistry, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad, India
Abstract
Synth. Commun. 2008, 38, 613
ONE‐POT SYNTHESIS OF 2‐(1‐ALKYL/ARALKYL‐1H‐BENZIMIDAZOLE‐2‐YL)‐QUINOXALINE DERIVATIVES USING MOLECULAR IODINE
P. K. Dubey, P. V. V. Prasada Reddy, and K. Srinivas
Deptartment of Chemistry, College of Engineering, JNT University, Kukatpally, Hyderabad India
Abstract
Synth. Commun. 2008, 38, 619
HIGHLY EFFICIENT SULFIMIDATION OF 1,3‐DITHIANES BY CU(I) COMPLEXES
L. Giribabu,1 Surya P. Singh,1 Nandkumar M. Patil,2 M. Lakshmi Kantam,1 Sunil P. Gupte,2 and Raghunath V. Chaudhari2
1Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, India
2Homogeneous Catalysis Division, National Chemical Laboratory, Pune, India
A series of four Cu(I) complexes were tested for sulfimidation of 1,3‐dithianes in the presence of [N‐(p‐tolysulfonyl)imino]phenyliodinane (PhI=NTs) as the nitrene‐transfer agent. Cu(TMPhen)(PPh3)Br is an efficient catalyst with more than 90% yield of the corresponding product with less reaction time as compared to the literature copper(I) complexes.
Abstract
Synth. Commun. 2008, 38, 626
N‐ARYLATION OF HETEROCYCLES WITH CHLORO‐ AND FLUOROARENES USING RESIN‐SUPPORTED SULFONATO‐CU(SALEN) COMPLEX
M. Lakshmi Kantam, T. Ramani, and L. Chakrapani
Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, India
Abstract
Synth. Commun. 2008, 38, 637
FACILE AND EFFICIENT SYNTHESIS OF 14‐ALKYL‐OR ARYL‐14‐H‐DIBENZO[A,J]XANTHENES USING SULFONYL‐FUNCTIONALIZED IONIC LIQUIDS
Pratibha Kumari, Vinith Yathindranath, and S. M. S. Chauhan
Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India
One‐pot condensation of 2‐naphthol with different aldehydes in the sulfonyl‐functionalized acidic ionic liquids gave 14‐alkyl‐ or aryl‐14‐H‐dibenzo[a,j]xanthenes in high yield at 125°C.
