Asymmetric Reduction of Prochiral Ketones with N‐Sulfonylated Amino Alcohols as Catalysts

Abstract

Novel N‐sulfonylated amino alcohols were synthesized from L‐amino acids and (+)‐camphor, and their application to asymmetric reduction of prochiral ketones with NaBH₄–BF₃ · Et₂O is described.

Keywords:

• asymmetric reduction
• ketone
• N‐sulfonylated amino alcohol

Acknowledgment

Financial support of this work by the Natural Science Foundation of Hubei Province (2007ABA291) is gratefully acknowledged.