Copper‐Catalyzed Coupling Reaction of 2‐Thioxo‐4‐quinazolinone and Thieno[3,2‐d]pyrimidin‐4‐one Methane Sulphonamide with Aryl Iodides: Preparation of Potential COX‐2 Selective Inhibitors

Abstract

Thio‐aryl methane sulfonamide derivatives of 4‐quinazolinone and thieno[2,3‐d]pyrimidin‐4‐one were synthesized using powdery copper/copper(I) iodide as catalyst; their structural elucidation is also reported. These derivatives were planned as sulfur bioisosteres of selective COX‐2 inhibitor drugs.

Keywords:

• copper catalyst
• COX‐2 selective inhibitors
• sulphonamides
• thio‐aryl derivatives