Synthesis of Tris(N,N-dimethylthiocarbamoyl)-1,1,1-tris-(methylaminomethyl)ethane and Its Application as Ligand for Pauson–Khand Reaction

Abstract

Tris(N,N-dimethylthiocarbamoyl)-1,1,1-tris(methylaminomethyl)ethane ligand was prepared from very cheap and commercially availably tris-1,1,1-(hydroxymethyl)ethane in five steps and applied as ligand in 1:1 coordination to cobalt in a catalytic Pauson–Khand reaction with Co₂(CO)₈ as catalyst.

Keywords:

• Pauson-Khand reaction
• tris-ureas
• tetrasubstituted thioureas
• tris-thioureas

ACKNOWLEDGMENT

The authors are grateful to the Fundação para a Ciência e Tecnologia (POCI 2010) and FEDER for financial support (Ref. SFRH/BPD/18740/2004 and POCI/QUI/56582/2004).

Notes

^a Isolated yield after purification by thin-layer chromatography (TLC).