Efficient Iron‐Catalyzed Sakurai–Michael Addition of Allyltrimethylsilane to Chalcones

Li‐Wen Xu Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, 310012, China; State Key Laboratory for Oxosynthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Lanzhou, ChinaCorrespondence[email protected]

Ming‐Song Yang Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, 310012, China

Hua‐Yu Qiu Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, 310012, China

Guo‐Qiao Lai Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, 310012, China

Jian‐Xiong Jiang Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, 310012, China

Abstract

A general catalytic conjugate addition with allyltrimethylsilane and chalcones is described. Allyltrimethylsilane undergoes the Sakurai–Michael reaction smoothly with high chemoselectivity in the presence of a catalytic amount of FeCl₃/TMSCl under very mild and convenient conditions to afford the corresponding Michael adducts in high yields.

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Acknowledgments

This study was partially supported by the National Natural Science Foundation of China (Project 20572114) and Hangzhou Normal University.

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Efficient Iron‐Catalyzed Sakurai–Michael Addition of Allyltrimethylsilane to Chalcones

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Efficient Iron‐Catalyzed Sakurai–Michael Addition of Allyltrimethylsilane to Chalcones

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