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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 8
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Original Articles

Synthesis of cis‐3‐methyl‐4‐aminopiperidine Derivatives

, , , &
Pages 1184-1193 | Received 30 Oct 2007, Published online: 17 Apr 2008
 

Abstract

A facile approach for the preparation of cis‐3‐methyl‐4‐aminopiperidine derivatives is described. The synthesis was carried out via regioselective ring opening of N‐benzyl‐3‐methyl‐3,4‐epoxi‐piperidine (8), which can be easily obtained in two steps from the corresponding N‐benzyl‐pyridinium salt (5). Seven new cis‐3‐methyl‐4‐amino and amido piperidines compounds were obtained.

Acknowledgments

The authors thank Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for the fellowships to F. F. H. and D. C. S.

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