Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 8
423
Views
27
CrossRef citations to date
0
Altmetric
Original Articles

New Procedure for One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones by Biginelli Reaction

, &
Pages 1299-1310 | Received 16 Aug 2007, Published online: 17 Apr 2008
 

Abstract

A practical green chemistry procedure for synthesis of 3,4‐dihydropyrimidin‐2(1H);‐ones in good yields was successfully carried out in micellar systems according to the Biginelli reaction using β‐ketoester, urea and appropriate aromatic aldehyde in the presence of CuCl2 · H2O as catalyst. The advantages of this method involved the broader application scope of substrates, the more environmental friendly process and the low‐cost of the Lewis acid catalyst.

Acknowledgments

This work was financially supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars (ROCS), State Education Ministry of China, and the startup fund of Shaanxi Normal University.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.