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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 10
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Original Articles

Simple and Convenient Synthesis of 4‐Unsubstituted‐3‐(3‐Oxoalkyl)isocoumarins

Alexander V. Butin Research Institute of Heterocyclic Compounds Chemistry, Kuban State University of Technology, Krasnodar, Russian FederationCorrespondence[email protected]
,
Artem S. Dmitriev Research Institute of Heterocyclic Compounds Chemistry, Kuban State University of Technology, Krasnodar, Russian Federation
,
Maxim G. Uchuskin Research Institute of Heterocyclic Compounds Chemistry, Kuban State University of Technology, Krasnodar, Russian Federation
,
Vladimir T. Abaev Department of Chemistry, North‐Ossetian State University, Russian Federation
&
Igor V. Trushkov Department of Chemistry, M. V. Lomonosov Moscow State University, Russian Federation
Pages 1569-1578 | Received 02 Oct 2007, Published online: 24 Apr 2008
 
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Abstract

A simple transformation of 2‐alkylfurans and 2‐formylbenzoic acids into 4‐unsubstituted 3‐(3‐oxoalkyl)isocoumarins is described. It is based on the synthesis of 2‐(2‐carboxybenzyl)furans followed by their acid‐catalyzed recyclization to the target isocoumarins.

Acknowledgment

Financial support was provided by the Russian Foundation of Basic Research (Grant 07‐03‐00352) and Bayer HealthCare AG (Germany).

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