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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 10
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Original Articles

Highly Efficient Heterobimetallic Iron‐Magnesium‐HMPA–Catalyzed Michael‐type Friedel–Crafts Reactions of Indoles and Chalcones

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Pages 1638-1645 | Received 15 Nov 2007, Published online: 24 Apr 2008
 

Abstract

A simple and novel bimetallic catalyst, an iron and magnesium complex (Fe‐Mg‐hexamethylphosphoramide (HMPA)), with dual activation was found to be an effective and promising catalyst for the Michael‐type Friedel–Crafts reactions of indoles with chalcones. This novel catalytic system has the advantages of highly efficient, mild reaction conditions and exhibits high reactivity and selectivity, which make it a useful and attractive process for the synthesis of indole derivatives.

Acknowledgments

This study was supported by the Natural Science Foundation of China (NSFC No. 20572114) for financial support of the work (NFSF No. 20572114) and Hangzhou Normal University.

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