Highly Efficient Heterobimetallic Iron‐Magnesium‐HMPA–Catalyzed Michael‐type Friedel–Crafts Reactions of Indoles and Chalcones

Wei Zhou State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Lanzhou, China; Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, China

Li Li Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, China

Li‐Wen Xu State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Lanzhou, China; Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, ChinaCorrespondence[email protected]

Hua‐Yu Qiu Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, China

Guo‐Qiao Lai Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, China

Chun‐Gu Xia State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Lanzhou, China

Anne‐Sophie Castanet Department of Organic Molecular Macromolecular Chemistry, Faculty of Science, University of Main and CNRS, Le Mans, France

show all

Abstract

A simple and novel bimetallic catalyst, an iron and magnesium complex (Fe‐Mg‐hexamethylphosphoramide (HMPA)), with dual activation was found to be an effective and promising catalyst for the Michael‐type Friedel–Crafts reactions of indoles with chalcones. This novel catalytic system has the advantages of highly efficient, mild reaction conditions and exhibits high reactivity and selectivity, which make it a useful and attractive process for the synthesis of indole derivatives.

Keywords:

Acknowledgments

This study was supported by the Natural Science Foundation of China (NSFC No. 20572114) for financial support of the work (NFSF No. 20572114) and Hangzhou Normal University.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Highly Efficient Heterobimetallic Iron‐Magnesium‐HMPA–Catalyzed Michael‐type Friedel–Crafts Reactions of Indoles and Chalcones

Information for

Open access

Opportunities

Help and information

Highly Efficient Heterobimetallic Iron‐Magnesium‐HMPA–Catalyzed Michael‐type Friedel–Crafts Reactions of Indoles and Chalcones

Abstract

Acknowledgments

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature