Three‐Component, One‐Pot Synthesis of Pyrazolo[3,4‐b]pyridine Derivatives in Aqueous Media

Abstract

6‐Amino‐4‐aryl‐5‐cyanopyrazolo[3,4‐b]pyridines were synthesized by a three‐component reaction of aromatic aldehydes, malononitrile, and 5‐amino‐3‐methyl‐1‐phenylpyrazole using sodium 1‐dodecanesulfonic (SDS) as catalyst in aqueous media. The reaction has the advantages of good yields, less pollution, ease of separation, and environmental friendliness.

Keywords:

• Aqueous media
• one‐pot synthesis
• pyrazolo[3,4‐b]pyridine
• three‐component reaction

Acknowledgments

We are grateful to the Surpassing Project Foundation of Jiangsu Province (QL9801) for financial support.