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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 10
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Original Articles

Three‐Component, One‐Pot Synthesis of Pyrazolo[3,4‐b]pyridine Derivatives in Aqueous Media

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Pages 1662-1669 | Received 05 Mar 2007, Published online: 24 Apr 2008
 

Abstract

6‐Amino‐4‐aryl‐5‐cyanopyrazolo[3,4‐b]pyridines were synthesized by a three‐component reaction of aromatic aldehydes, malononitrile, and 5‐amino‐3‐methyl‐1‐phenylpyrazole using sodium 1‐dodecanesulfonic (SDS) as catalyst in aqueous media. The reaction has the advantages of good yields, less pollution, ease of separation, and environmental friendliness.

Acknowledgments

We are grateful to the Surpassing Project Foundation of Jiangsu Province (QL9801) for financial support.

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