Simple and Efficient Synthesis of 3-(N-Hydroxylamino)-1,3-diarylpropan-1-one Oximes Under Ultrasound Irradiation

Abstract

A series of 3-(N-hydroxylamino)-1,3-diarylpropan-1-one oximes have been synthesized through the reaction of chalcones and hydroxylamine hydrochloride in 56–96% yield within 2–3 h in the presence of sodium acetate in EtOH under ultrasound irradiation.

Keywords:

• 3-(N-Hydroxylamino)-1
• 3-diarylpropan-1-one oximes
• sodium acetate
• ultrasound irradiation

ACKNOWLEDGMENTS

We thank the Natural Science Foundation of Hebei Province (B2006000969), China, for financial support.

Notes

^a Reaction temperature: 36–40°C, substrate: PhCOCH = CHPh: 2 mmol; amount of NaAc: 0.492 g.

^b Stirred without ultrasound irradiation.