Abstract
Cl3CCONH2/PPh3 was a versatile reagent to convert carboxylic acids into their corresponding acid chlorides. This intermediate was clearly confirmed by spectroscopic methods (IR, 1H, 13C NMR). This one-pot reaction of in situ acid chloride generated with various alcohols successfully furnished the corresponding esters in moderate to excellent yields.
ACKNOWLEDGMENTS
Financial support from the Thailand Research Fund through the Royal Golden Jubilee Ph.D. Program (Grant No. PHD/0223/2548) to O. C. and W. C. is acknowledged. O. C. and W. C. are also indebted to the Graduate School, Chulalongkorn University, for a grant. One of us (D. O. J.) is also grateful for the support from Institute for NanoBio Molecular Assemblies.
Notes
a 3 equiv of t-butylalcohol and 6 h for step 2 were used.
a 1.2 equiv of acetic acid.
b 2 equiv of acetic acid.
c Room temperature (28–30°C) in step 2.
a Step 2 for 3 h.