Abstract
Direct reductive amination of aldehydes and ketones were accomplished efficiently using high-capacity, ionene-based, polymer-supported borohydride reagent in isopropyl alcohol at reflux under neutral conditions. The reagent is easily prepared by mixing aqueous solution of 2,4-ionene bromide with an alkaline solution of sodium borohydride at room temperature. The generality of reaction was established using both aliphatic and aromatic aldehydes, ketones, and amines.
ACKNOWLEDGMENT
Financial support of this work from the Research Council of Mazandaran University gratefully acknowledged.
Notes
a All reactions were carried out under reflux, and the molar ratio of reagent/carbonyl compound/amine was 2/1/1.2.
b All products were characterized spectroscopically (1H NMR, IR) and showed physical and spectral data in accordance with their expected structure and by comparison with authentic samples.
c Yields refer to pure isolated products.