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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2008 - Issue 2
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Original Articles

Proline-Catalyzed Simple and Efficient Synthesis of 1,8-Dioxo-decahydroacridines in Aqueous Ethanol Medium

K. Venkatesan Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, India
,
Suresh S. Pujari Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, India
&
Kumar V. Srinivasan Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune, IndiaCorrespondence[email protected]
Pages 228-241 | Received 16 Jan 2008, Published online: 22 Dec 2008
 
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Abstract

Proline-catalyzed synthesis of 1,8-dioxo-decahydroacridines is achieved via one-pot, three-component condensation of aromatic aldehydes, cyclic diketone, and aryl amines in aqueous ethanol medium. This method offers the advantages of proceeding in neutral and mild conditions, giving high to excellent yields of acridines with easy workup procedure.

ACKNOWLEDGMENT

K.V. thanks University Grants Commission, New Delhi, for providing a research fellowship.

Notes

a Yields reported are after recrystallization.

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