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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 21
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Original Articles

Efficient Synthesis of Quinoxalines in the Ionic Liquid 1-n-Butylimidazolium Tetrafluoroborate ([Hbim]BF4) at Ambient Temperature

, &
Pages 3601-3612 | Received 15 Feb 2008, Published online: 14 Oct 2008
 

Abstract

Quinoxaline derivatives have been synthesized in excellent yields using an ionic liquid (IL) (viz., 1-n-butylimidazolium tetrafluoroborate) as a reaction medium as well as promoter from various 1,2-diketones and aryl-1,2-diamines. The process is general for the synthesis of quinoxaline derivatives from aromatic as well as aliphatic-1,2-diketones. The advantages of the present method are ambient reaction temperature, simplicity of operation, high yields of products, the recyclability of the IL, and ecofriendly nature of the reaction medium.

ACKNOWLEDGMENTS

T. M. P. thanks the Council of Scientific and Industrial Research (CSIR), New Delhi, for the award of a research fellowship.

Notes

a The pKa values of the parent acid of the anions.

b Isolated yield after column chromatography.

a Isolated yield after column chromatography.

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