Simple Synthesis of P¹P²-Diadenosine 5′-Pyrophosphate

Enrico Millo Department of Experimental Medicine, Biochemistry Section, Center of Excellence for Biomedical Research, University of Genoa, Genoa, ItalyCorrespondence[email protected]

Elena Zocchi Department of Experimental Medicine, Biochemistry Section, Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy

Andrea Galatini Department of Chemistry and Industrial Chemistry, University of Genoa, Genoa, Italy

Umberto Benatti Department of Experimental Medicine, Biochemistry Section, Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy

Gianluca Damonte Department of Experimental Medicine, Biochemistry Section, Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy

Abstract

Pyrophosphate-linked coenzymes play essential roles in several biochemical systems. Symmetrical diadenosine-5′-pyrophosphate (Ap2A) has been synthesized from adenosine-5′-phosphate in virtually quantitative yield. The simple procedure is carried out in anhydrous pyridine using adenosine phosphoromorpholidate and adenosine monophosphate bis-(tri-n-butylammonium salt) as coupling reagents.

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ACKNOWLEDGMENTS

The authors are grateful for the help and technical assistance of Andrea Armirotti. This work was supported by grants from the Italian Association for Cancer Research (AIRC), the Italian Ministry for Education, University and Scientific Research (Grants MIUR-PRIN 2003, MIUR FIRB RBNE01ERXR, and MIUR FIRB RBLA039LSF), and the Fondazione Cassa di Risparmio di Genova e Imperia.

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Simple Synthesis of P¹P²-Diadenosine 5′-Pyrophosphate

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Simple Synthesis of P¹P²-Diadenosine 5′-Pyrophosphate