New Method for the Synthesis of 2-Acylamino-1-benzothiophene-3-carboxamide Derivatives from the Corresponding Esters

Péter Bánhegyi Cooperative Research Centre, Semmelweis University, Budapest, Hungary; Vichem Chemie Research Ltd., Budapest, Hungary

Frigyes Wáczek Cooperative Research Centre, Semmelweis University, Budapest, Hungary; Vichem Chemie Research Ltd., Budapest, Hungary

Zsolt Székelyhidi Cooperative Research Centre, Semmelweis University, Budapest, Hungary; Vichem Chemie Research Ltd., Budapest, Hungary

Bálint Hegymegi-Barakonyi Cooperative Research Centre, Semmelweis University, Budapest, Hungary; Vichem Chemie Research Ltd., Budapest, Hungary

György Kéri Vichem Chemie Research Ltd., Budapest, Hungary; Semmelweis University, Pathobiochemistry Research Group, Hungarian Academy of Sciences, Budapest, Hungary

László Őrfi Vichem Chemie Research Ltd., Budapest, Hungary; Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, HungaryCorrespondence[email protected]

Abstract

An unusual chemical method has been applied for the preparation of 1-benzothiophene-3-carboxamide derivatives from esters by reaction with lithium amide in tetrahydrofurane.

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ACKNOWLEDGMENTS

The authors thank Ildikó Szilágyi, István Varga, Zoltán Horváth, and Péter Markó for their technical contributions to this work and Csaba Peltz (EGIS Ltd.) for the elemental analysis. This work was supported by OTKA-T-049478, NKFP-1A0020/2002 (MOL.DIAG), NKFP-1A005_04 (MEDICHEM2), and New Medicines for Tuberculosis (LSHP-CT-2005–018923) grants.

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New Method for the Synthesis of 2-Acylamino-1-benzothiophene-3-carboxamide Derivatives from the Corresponding Esters

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New Method for the Synthesis of 2-Acylamino-1-benzothiophene-3-carboxamide Derivatives from the Corresponding Esters

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