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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 19
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Original Articles

Synthesis of Protected Dithiol Amino Acids for Potential Use in Peptide Chemistry

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Pages 3303-3310 | Received 22 Dec 2007, Published online: 12 Sep 2008
 

Abstract

Two N-Fmoc and S,S′-protected α-amino acids were synthesized by introducing the derivatives of dithioether into a Tyrosine side chain under the Mitsunobu protocol using the diisopropylazodicarboxylate/triphenylphosphine (DIAD/TPP) system. These amino acids provide a potential use in peptide chemistry.

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