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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 20
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Original Articles

Ionic Liquid–Mediated Synthesis of Coumarin-3-carboxylic Acids via Knoevenagel Condensation of Meldrum's Acid with ortho-Hydroxyaryl Aldehydes

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Pages 3508-3513 | Received 12 Feb 2008, Published online: 30 Sep 2008
 

Abstract

A simple, efficient, and green protocol for synthesis of coumarin-3-carboxylic acids is described via Knoevenagel condensation of Meldrum's acid with ortho-hydroxyaryl aldehydes in [Hmim]Tfa ionic liquid, which was found to give better results than other ionic liquids. Furthermore, ionic liquid is easily reused without any appreciable loss in activity.

ACKNOWLEDGMENTS

The authors are thankful to the Council of Scientific and Industrial Research (CSIR, New Delhi) and the Defence Research and Development Organisation (DRDO, New Delhi) for the financial support. N. B. D., S. V. B., and D. J. R. are thankful to CSIR for the award of senior research fellowships.

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