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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 20
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Original Articles

Efficient NaOH-Catalyzed Reaction of Aromatic Aldehyde, Cyclic Ketones, and Malononitrile Under Solvent-Free Conditions Using a Grinding Method

, , &
Pages 3530-3542 | Received 02 Feb 2008, Published online: 29 Sep 2008
 

Abstract

An efficient and facile synthesis of 2,6-dicyanoanilines via a one-pot reaction of aromatic aldehydes, malononitrile, and cyclic ketones in the presence of NaOH under solvent-free conditions using a grinding method has been developed. Compared with the classical reaction conditions, the new synthetic method has the advantages of excellent yields, shorter reaction times, and mild reaction conditions.

ACKNOWLEDGMENTS

We thank the PeiYu Foundation (07PYL06) of Xuzhou Normal University for financial support.

Notes

a Reagents and conditions: 4-methylbenzaldehyde 1 (2 mmol), malononitrile 2 (5 mmol), cyclohexanone 3 (2 mmol), and NaOH (0.2 g).

b Isolated yields.

c Basic.

a Reagents and conditions: 4-methylbenzaldehyde 1 (2 mmol), malononitrile 2 (5 mmol).

b Isolated yields.

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