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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 20
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Original Articles

Synthesis of New 2-Aryl Substituted 2,3-Dihydroquinazoline-4(1H)-ones Under Solvent-Free Conditions, Using Molecular Iodine as a Mild and Efficient Catalyst

, , , &
Pages 3567-3576 | Received 05 Feb 2008, Published online: 29 Sep 2008
 

Abstract

A simple, inexpensive, and efficient one-pot synthesis of 2,3-dihydroquinazoline-4(1H)-one derivatives under solvent-free conditions using a catalytic amount of iodine with excellent product yields is reported. This methodology provides easy, quantitative access to various 2,3-dihydroquinazoline-4(1H)-one derivatives, using commercially available iodine as a catalyst.

ACKNOWLEDGMENT

The authors gratefully acknowledge the Research Council of K. N. Toosi University of Technology for partial financial support of this work.

Notes

a Isolated yields.

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