LiBr: A Mild Lewis Acid Catalyst for Efficient One-Pot Synthesis of α-Amino Nitriles

Abstract

α-Amino nitriles are synthesized in a one-pot, three-component coupling of aldehydes, amines, and trimethylsilyl cyanide using a catalytic amount of LiBr at ambient temperature.

Keywords:

• LiBr
• Strecker nitriles
• trimethylsilyl cyanide

ACKNOWLEDGMENT

The authors are thankful to the Council of Scientific and Industrial Research, New Delhi, India, for financial assistance and to the Indian National Science Academy for additional financial support for this research project.

Notes

^a The products were characterized by comparison of their melting points and spectral (IR, ¹H NMR) data with those of authentic samples.

^b Isolated yields after recrystallization.