Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 21
1,162
Views
115
CrossRef citations to date
0
Altmetric
Original Articles

Click Reaction: Highly Efficient Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

, &
Pages 3751-3759 | Received 05 May 2008, Published online: 14 Oct 2008
 

Abstract

In this work, condensation reaction of 2-aminobenzamide with various alkyl, aryl, and alicyclic aldehydes or ketones to 2,3-dihydroquinazolin-4(1H)-one derivatives in the presence of a catalytic amount of ammonium chloride in ethanol at room temperature is described. This reaction can be classified as a click chemical synthesis because of its high yields, short reaction times, and green and efficient reaction medium.

ACKNOWLEDGMENT

We gratefully acknowledge the financial support from the Research Council of Shahid Beheshti University.

Notes

a Isolated yield.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.