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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 21
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Original Articles

Kumada–Corriu Cross Coupling Route to the Anti-Cancer Agent Combretastatin A-4

Pages 3823-3833 | Received 15 Jan 2008, Published online: 14 Oct 2008
 

Abstract

A short and efficient synthesis of the anticancer agent combretastatin A-4 was accomplished from inexpensive starting materials using the iron-catalyzed cross-coupling of a Grignard reagent and a bromostilbene as the key step.

ACKNOWLEDGMENT

Support by James W. Herndon, Department of Chemistry and Biochemistry, New Mexico State University, USA, is gratefully acknowledged.

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