Synthesis and Characterization of a New Series of Hydroxy Pyrazolines

Abstract

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one obtained by Claisen–Schmidt condensation of 2-acetyl thiophene with benzaldehyde was converted into 2,3-dibromo-3-phenyl-1-(thiophen-2-yl)propan-1-one, which on treatment with various thiosemicarbazides in the presence of triethylamine in absolute ethanol, yielded the corresponding hydroxy pyrazolines 3a–h. All the compounds were characterized by IR, ¹H NMR, and ¹³C NMR spectra.

Keywords:

• Chalcone
• chalcone dibromide
• hydroxy pyrazoline
• pyrazoline

ACKNOWLEDGMENTS

This work was supported by the Department of Science and Technology (Grant No. Vll-PRDSF/44/2004-05/TT), New Delhi, India.