Aminolysis of Epoxides in Ionic Liquid 1-Ethylpyridinium Trifluoroacetate as Green and Efficient Reaction Medium

Abstract

Aminolysis of epoxides has been carried out using the ionic liquid 1-ethylpyridinium trifluoroacetate ([EtPy][TFA]) as reaction medium. The reactions went smoothly under mild conditions without any catalyst to afford corresponding β-aminoalcohols in high conversions. Moreover, further enhancement in the conversions was observed when AlCl₃ was used as Lewis acid catalyst.

Keywords:

• β-Amino alcohols
• aminolysis
• epoxides
• ionic liquids

ACKNOWLEDGMENT

R. P. A. acknowledges Bristol-Myers Squibb, Lawrenceville, N. J. USA, for summer undergraduate research support.

Notes

^a Yield (%)/time (h).