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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 23
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Original Articles

Alternative Synthesis of Tadalafil: PDE5 Inhibitor

, , , , , , & show all
Pages 4265-4271 | Received 03 May 2008, Published online: 31 Oct 2008
 

Abstract

Two-step alternative synthesis of tadalafil (1) is described. The synthesis features Pictet–Spengeler type reaction and DCC (N,N′-dicyclohexylcarbodiimide)/HOBt (N-hydroxybenzotriazole)–mediated double amidation employing sarcosine ethyl ester hydrochloride.

ACKNOWLEDGMENTS

The authors thank the management of Dr. Reddy's Laboratories Ltd. for supporting this work.

Notes

DRL-IPD Communication Number IPDO-IPM-00116.

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