Synthesis of Amphiphilic Amino Alcohols

Abstract

An efficient and general approach for the synthesis of amphiphilic 1,2-amino alcohols is reported. The use of N-benzyl protecting groups is essential for obtaining good yields when opening a long-chain terminal epoxide with an amine.

Keywords:

• Amino alcohols
• amphiphiles
• epoxide opening
• N-benzyl protecting group

Notes

^a Isolated yield.

^b Ncd—no conversion detected.