Abstract
A short, convenient, high-yielding, and economical synthesis of 4-N,N-dimethylaminopiperidine is described. The key step is the palladium-catalyzed reductive amination of 4-piperidone.
ACKNOWLEDGMENTS
The authors thank Dr. F. Reutter and Dr. H. V. Joshi for helpful discussions, Mrs. D. Kumbhar for help with the experiments, and Mr. Y. S. Lakshminarasimham for analytical support.