Efficient Synthesis of Olmesartan Medoxomil, an Antihypertensive Drug

Abstract

This document describes a simple and robust process for the synthesis of olmesartan medoxomil. This tailored process allows us to synthesize olmesartan medoxomil on a large scale with 50% overall yield. Also, our process has excellent control of the impurity profile in all the stages.

Keywords:

• Angiotensin receptor antagonist
• anti-hypertensive
• olmesartan

ACKNOWLEDGMENT

We greatly appreciate the supportive environment encouraged at Dr. Reddy's Laboratories Ltd. We are thankful to Intellectual Property Management, NMR group of Dr. Reddy's Research Foundation, and the analytical group of Integrated Product Development Organization for their generous support.

Notes

DRL-IPD Communication No. IPDO-IPM-00114