Oxidative Cleavage of Epoxides Using Aqueous Sodium Paraperiodate

Abstract

A simple and mild method in water for direct conversion of epoxides to corresponding aldehydes has been developed using sodium paraperiodate (Na₃H₂IO₆). High yields of corresponding aldehydes were obtained.

Keywords:

• Aldehydes
• epoxides
• sodium paraperiodate

ACKNOWLEDGMENT

We gratefully acknowledge University Grants Commission (UGC), India, for financial support a UGC major research project.

Notes

^a Typically, Na₃H₂IO₆ (12 mmol) reacted with epoxide (10 mmol) in water (25 mL) at room temperature.

^b Starting compounds were prepared by standard literature procedures.

^c Isolated yields after column chromatography and structure confirmed by comparison of IR and ¹H NMR with those of authentic materials.