Catalyst-Free Synthesis of α,α-bis(4-Hydroxycoumarin-3-yl)toluene in Aqueous Media Under Microwave Irradiation

Abstract

An efficient catalyst-free synthesis of α,α-bis(4-hydroxycoumarin-3-yl)toluene was performed by the reaction of 4-hydroxycoumarin with aromatic aldehydes in aqueous media under microwave irradiation. The reaction was completed in short reaction time of 8–10 min with high yields of 76–94, was environmental benign, and had easy workup. Their structures were confirmed by IR spectra, ¹H NMR, ¹³C NMR, and elemental analysis.

Keywords:

• Aqueous media
• aromatic aldehyde
• α,α-bis(4-hydroxycoumarin-3-yl)toluene
• 4-hydroxycoumarin
• microwave irradiation

ACKNOWLEDGMENT

We thank the Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials for financial support.

Notes

^a Microwave power: 150 W; reactive temperature: 150 °C.

^b Yields of the isolated products.