Bismuth Chloride–Sodium Nitrite: A Novel Reagent for Chemoselective N-Nitrosation

Abstract

Bismuth(III) chloride–sodium nitrite was used as a mild and efficient reagent for N-nitrosation of various tetrazoles, secondary amines, and amides under ambient conditions. Nitrosation took place chemoselectively at the nitrogen atom, giving corresponding N-nitroso derivatives in good to excellent yield.

Keywords:

• Bismuth(III) chloride
• N-nitrosation
• nitrosotetrazoles
• nitrosamides
• nitrosamines

ACKNOWLEDGMENT

Authors are grateful to acknowledge the financial support from the University Grant Commission (UGC), New Delhi. The authors are also thankful to Dr. S. T. Gadade, principal, C. K. Thakur College, for providing laboratory and other facilities.