Efficient Synthesis of 7-Amino-3-hydroxyindan-1-one

Raj (S. B.) Rajur CreaGen Biosciences, Inc., Woburn, Massachusetts, USA

Venugopal N. Rao CreaGen Biosciences, Inc., Woburn, Massachusetts, USA

Hwa-Ok Kim CreaGen Biosciences, Inc., Woburn, Massachusetts, USA

Pamela Nagafuji CreaGen Biosciences, Inc., Woburn, Massachusetts, USA

Xavier Hearult CreaGen Biosciences, Inc., Woburn, Massachusetts, USA

John D. Williams Microbiotix, Inc., Worcester, Massachusetts, USA

Norton P. Peet CreaGen Biosciences, Inc., Woburn, Massachusetts, USA; Microbiotix, Inc., Worcester, Massachusetts, USACorrespondence[email protected]

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Abstract

An efficient and reliable three-step synthesis of 7-amino-3-hydroxyindan-1-one (7) is described. Compound 7 is a versatile, three-dimensional, three-point scaffold that is useful for the construction of focused compound libraries.

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Notes

^aIsolated yields.

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Efficient Synthesis of 7-Amino-3-hydroxyindan-1-one

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Efficient Synthesis of 7-Amino-3-hydroxyindan-1-one

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