Palladium on Carbon-Catalyzed Cross-Coupling of Aryl Halides with Potassium p-Tolyltrifluoroborate in Air

Abstract

Palladium supported on carbon (Pd/C) has been shown to be an effective catalyst for the cross-coupling of potassium p-tolyltrifluoroborate with a variety of aryl bromides and iodides. Yields ranging from moderate to good were obtained using Pd/C in ethanol/water mixtures with potassium carbonate as base at 50 °C under an air atmosphere.

Keywords:

• Cross-coupling reaction
• palladium catalysis
• potassium p-tolyltrifluoroborate
• Suzuki–Miyaura reaction

Notes

Note. Conditions: ethanol/water (5/1), Pd/C (10 mol%), and K₂CO₃ (2 eq.) at 50 °C for 24 h.