Three-Component One-Pot Synthesis of Polyhydroacrodine Derivatives in Aqueous Media

Abstract

9,10-Diaryldecahydroacridine-1,8-diones were synthesized by a three-component reaction of aromatic aldehydes, aromatic amines, and 5,5-dimethyl-1,3-cyclohexanedione using sodium 1-dodecanesulfonic (SDS) as the catalyst in aqueous media. The key intermediates before the cyclization step were obtained and characterized. The structures of all the products were determined by IR and ¹H NMR spectra and further confirmed by single-crystal x-ray diffraction analysis.

Keywords:

• Aqueous media
• one-pot synthesis
• polyhydroacridine
• three-component reaction

ACKNOWLEDGMENTS

We are grateful to the Foundation of Key Laboratory of Biotechnology on Medical Plants of Jiangsu Province for financial support.