Efficient One-Pot Synthesis of 2-Chloro-1,1, 1-trifluoro-2-alkenes Under Solvent-Free Conditions

Abstract

The improved one-pot Wittig reaction had been used to prepare trifluoromethyl-containing olefins under solvent-free conditions. Treatment of aldehydes with PPh₃ and CF₃CCl₃ in the presence of K₂CO₃ at 100 °C afforded 2-chloro-1,1,1-trifluoro-2-alkenes in good to moderate yields.

Keywords:

• Olefins
• one pot
• solvent free
• trifluoromethyl
• Wittig reaction

ACKNOWLEDGMENT

We thank the Office of Education of Zhejiang Province (20070535) and Wenzhou Municipal Science and Technology Bureau (G20060075) for financial support.

Notes

^a Reaction conditions were 1a (5 mmol), CF₃CCl₃ (6 mmol), PPh₃ (5/10 mmol), and K₂CO₃ (0.5/5 mmol) at 90 °C for 8 h.

^b Isolated yield.

^a Isolated yield.

^b Z/E ratios were determined by ¹H NMR.