Alkali Salt of L-Proline as an Efficient and Practical Catalyst for the Cyanosilylation of a Wide Variety of Carbonyl Compounds Under Solvent-Free Conditions

Abstract

The alkali salt of L-proline was demonstrated to be an efficient and practical catalyst for the cyanosilylation of a wide variety of simple and functionalized carbonyl compounds under solvent-free conditions. The reactions proceeded smoothly at room temperature to afford the corresponding cyanohydrins in good to excellent yields.

Keywords:

• Cyanohydrin
• cyanosilylation
• L-proline salt
• solvent-free condition
• TMSCN

ACKNOWLEDGMENT

This work was partially supported by the Key Laboratory of Organic Synthesis of Jiangsu Province at Suzhou University (No. S8109108), the Natural Science Foundation of Jiangsu Province (No. BK2006048), the National Science Foundation of China (Nos. 20472062 and 20672079), the Nature Science Key Basic Research of Jiangsu Province for Higher Education (Nos. 06KJA15007 and 05KJB150116), the Jiangsu Provincial Key Laboratory of Fine Petrochemical Technology (KF0402), and a research grant from the Innovation Project for Graduate Students of Jiangsu Province.

Notes

^a Isolated yield.

^b Solvent-free condition.

^a Isolated yield.

^a Isolated yield.