Efficient Method for the Synthesis of Michael Adducts Using Kaolin Preloaded with KOH

Abstract

Michael addition of various active methylene compounds to β-nitrostyrenes is efficiently catalyzed by using Kaolin preloaded with KOH in acetonitrile at room temperature with moderate to good yields.

Keywords:

• Active methylene compounds
• kaolin/KOH
• Michael reaction
• nitrostyrenes

ACKNOWLEDGMENT

We thank Dr. J. S. Yadav (director) and Dr. V. V. N. Reddy (head of department) of the Indian Institute of Chemical Technology, Hyderabad, for constant encouragement and financial support.

Notes

^a All products were characterized by IR, ¹H NMR, and mass spectroscopy.

^b Unoptimized, isolated yields.