Novel Synthesis of Anthelmintic Drug 4-Isothiocyanato-4′-nitrodiphenyl Ether and Its Analogs

Abstract

An efficient, mild, chemoselective, and convenient protocol for synthesis of isothiocyanate derivatives. This protocol was applied successfully in the novel synthesis of anthelmintic drug 4-isothiocyanato-4′-nitrodiphenyl ether and its analogs.

Keywords:

• Amines
• carbon disulfide
• ferrous sulfate
• isothiocyanates
• triethylamine

ACKNOWLEDGMENT

The authors gratefully acknowledge for the financial support from the University Grants Commission, New Delhi. The authors are thankful to Dr. S. T. Gadade, principal, C. K. Thakur College, for providing laboratory and other facilities. The authors are also thankful to Cipla Ltd. for help with the analytical analysis.