Efficient One-Pot Synthesis of 4-Aryl-3-cyano-2,5-dihydro-1H-indeno[1,2-b]pyridin-2-one and 4-Aryl-3-cyano-1,2,5,6-tetrahydrobenzo[h]quinolin-2-one Derivatives Under Solvent-Free Conditions

Abstract

4-Aryl-3-cyano-2,5-dihydro-1H-indeno[1,2-b]pyridin-2-one and 4-aryl-3-cyano-1,2,5,6-tetrahydrobenzo[h]quinolin-2-one have been prepared from indan-1-one or 3,4-dihydronaphthalen-1(2H)-one, aromatic aldehydes, 2-cyanoacetamide, in the presence of sodium hydroxide under solvent-free conditions. The rapid and facile method produced products in high yields.

Keywords:

• 2-Cyanoacetamide
• 3-cyano-2-pyridones
• one-pot reactions
• solvent free
• synthesis

ACKNOWLEDGMENTS

We thank the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017), the National Natural Science Foundation of China (No. 20772103), and the PeiYu Foundation (No. 07PYL06) of Xuzhou Normal University for financial support.