Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 6
978
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Novel Sc(OTf)3/3-HQD Catalyst for Morita–Baylis–Hillman Reaction

, &
Pages 1035-1045 | Received 26 Mar 2008, Published online: 25 Feb 2009
 

Abstract

A novel and efficient catalytic system of the Morita–Baylis–Hillman (MBH) reaction between aromatic aldehyde and activated alkenes has been developed. The novel system of a combination of Sc(OTf)3 and 3-hydroxyquinuclidine (3-HQD) showed a high catalytic activity for the MBH reaction.

Notes

a Reaction conditions: 3.0 mmol of methyl acrylate, 1.0 mmol of p-nitrobenzaldehyde, 100 mmol% of Lewis base using CH3CN as solvent.

b Isolated yield based on p-nitrobenzaldehyde.

a Isolated yield based on p-nitrobenzaldehyde.

a Reaction conditions: 3.0 mmol of α,β-unsaturated ester, 1.0 mmol of aromatic aldehydes, 5 mmol% of Sc(OTf)3, and 20 mmol% of Lewis base using DMF as solvent.

b Isolated yield based on aromatic aldehyde.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.