Three-Component Synthesis of Pyrimidine and Pyrimidinone Derivatives in the Presence of High-Surface-Area MgO, a Highly Effective Heterogeneous Base Catalyst

Abstract

Magnesium oxide (MgO) effectively catalyzes the three-component reaction of aldehydes, amidine systems, and malononitrile or ethyl cyanoacetate to form 4-amino-5-pyrimidine carbonitrile and pyrimidinone derivatives, respectively. The salient features of this method include high conversions, short reaction times, cleaner reaction profiles, and the use of inexpensive and readily available catalyst.

Keywords:

• Amidines
• 4-amino-5-pyrimidinecarbonitriles
• magnesium oxide (MgO)
• malononitrile
• three-component reaction

ACKNOWLEDGMENTS

The authors express their appreciation to the Shahid Bahonar University of Kerman Faculty Research Committee for its support of this investigation.